Nuclear Magnetic Resonance (NMR)

Storrs
Center for Open Research Resources and Equipment

The Nuclear Magnetic Resonance Facility recognizes the important role that NMR plays in molecular structure determination and conformational analysis for research projects engaging chemical synthesis, chemical mixture characterization, drug design, intermolecular interaction studies, protein and nucleic acid characterization. The joint NMR Facility of COR²E and the Department of Chemistry offers several solution-state NMR instruments on a fee-for-use basis. The instrumentation serves the high-resolution research needs for investigators from the University of Connecticut and nearby colleges and companies.

Services

  • The solution-state 500 and 600 MHz NMR instruments are offered on a fee-for-use 24/7 basis.
  • The staff provides training and consultation on the use of the instruments.
  • The staff provides expertise on the experiment planning and data analysis.
  • The dedicated Network Attached Storage for NMR data transfer and archive is available.
  • The instruments' time and other services can be reserved at https://cider.uconn.edu/facilities/NMR. This webpage also provides additional details about the NMR Facility

Varian INOVA 600

Fitted with a triple-resonance (1H, 13C, 15N) inverse cryogenic probe, the Varian 600 has a superior proton sensitivity (signal-to-noise ratio ~4500). Owing to a high proton sensitivity, the 600 is an instrument of choice for characterization of submicrogram quantities of soluble organic compounds and the natural products via the proton-detected experiments: 1H one-dimensional spectra, 1H-1H, 1H-13C, and 1H-15N two-dimensional correlation spectra (COSY, TOCSY, NOESY, HSQC, HMBC, etc). The spectrometer is also fully equipped to carry out the biomolecular multidimensional (3D, 4D) NMR experiments and Diffusion Ordered Spectroscopy (DOSY) experiments. The Varian 600 can be found in the Chemistry Building, room R002.

Internal External (non-profit) External (for-profit)
Unassisted $17/hour $50/hour $90/hour 
Assisted Contact $90/hour  $150/hour
Consulting/Set-Up/Training $100/hour $120/hour  $150/hour
Varian INOVA 600

Bruker AVANCE 500

This walk-up spectrometer is equipped with the broadband 5 mm BBFO SmartProbe that can automatically select, optimally tune, and match with the auto tune-match (ATM) component to any nuclei in the resonance frequency range between 15N-31P. Besides, this BBFO probe has the added ability to observe 19F with 1H decoupling and vice-versa, as well as to perform 1H-19F 2D correlation spectroscopy. The probe has a signal-to-noise ratio 730 for 1H, 550 for 19F, 300 for 13C, 180 for 31P and 40 for 15N. The Bruker AVANCE 500 is an instrument of choice for users with small quantities of a compound and for multidimensional experiments such as HSQC, HMBC or NOESY. It is used when a higher resolution NMR is necessary for chemical structure elucidation and it supports NMR studies on proteins and nucleic acids. The spectrometer is located in the Pharmacy/Biology Building, room 056.

The Department of Chemistry also houses the solution-state Bruker AVANCE III 400 MHz equipped with the two-channel console and a 5mm BBFO probe with 19F capability, and the Bruker AVANCE 300 MHz fitted with a 5mm BBO probe, both instruments have the ATM component.

Internal External (non-profit) External (for-profit)
Unassisted $17/hour $50/hour $90/hour 
Assisted Contact $90/hour  $150/hour
Consulting/Set-Up/Training $100/hour $100/hour  $150/hour
NMR facility