Nuclear Magnetic Resonance (NMR)

Storrs
Center for Open Research Resources and Equipment

The Nuclear Magnetic Resonance Facility recognizes the important role that NMR plays in molecular structure determination and conformational analysis for research projects engaging chemical synthesis, chemical mixture characterization, drug design, intermolecular interaction studies, protein and nucleic acid characterization. The joint NMR Facility of COR²E and the Department of Chemistry offers several solution-state NMR instruments on a fee-for-use basis. The instrumentation serves the high-resolution research needs for investigators from the University of Connecticut and nearby colleges and companies.

Campus Address

Varian INOVA 600:
Chemistry Building, Room R002

Bruker Avance 500:
Pharmacy Biology Building, Room 056

Mailing Address

Flow Cytometry Facility
Center for Open Research Resources and Equipment
91 North Eagleville Road, Unit 3149
Storrs, CT 06269

Training and Education

Only trained users can be granted access to the NMR spectrometers. The NMR Facility Staff provides training and consultation in the use of instruments under their respective supervision. A 24 hour notice is required for scheduling a hands-on training session. For specific questions regarding NMR applications and for general managerial questions, please contact the NMR Facility Director.

Research Potential

The NMR Facility directly supports and impacts research programs in the following areas:

  • Chemical synthesis
  • Analysis of Chemical Mixtures
  • Pharmaceutical chemistry
  • Molecular recognition & drug binding
  • Nanomaterials
  • Macromolecules
  • Protein structure-function relationships
  • Protein folding and design
  • Nucleic acid structure and reactivity
  • Molecular dynamics

The provided instruments are used for a wide range of problems. The most frequent involve monitoring the chemical synthesis, drug discovery and development, material science, the molecular structure determination and ligand-protein interactions. The instruments are capable of carrying out molecular diffusion measurements, identifying metabolites in mixtures, and following reaction kinetics, just to cite a few examples.